Factors Affecting the Risk of Mental Disorders in Patients With Bipolar Disorder in the West of Iran


Background: Drug addiction, obsessive compulsive disorders (OCD), and other anxiety disorders are the disorders most commonly found in patients with bipolar disorder.

Objectives: The purpose of this study was to identify the factors affecting the risk of drug addiction, obsessive compulsive disorders, and other anxiety disorders in patients with bipolar disorder.

Patients and Methods: In this retrospective cohort study, the medical records of 400 patients with bipolar disorder hospitalized in Hamadan, Iran, between 2008 and 2014 were examined. Patient information, including demographic characteristics and comorbidity, was collected. A data analysis was performed using a separate logistic regression for each disorder. The statistical package used was STATA software version 11. A P-value of less than 0.05 was considered statistically significant.

Results: The mean (SD) age of the patients with bipolar disorder was 34.62 (1.68) years. Of the 400 patients with bipolar disorder, 135 (33.75%) patients had anxiety disorders, 67 (16.8%) patients suffered from drug addiction, and 45 (11%) patients had OCD. An association was established between drug addiction and OCD, and gender (P ≤ 0.05). The ORs of anxiety disorders, drug addiction, and OCD were 1.05 (95% CI = 0.65 - 1.68), 0.26 (95% CI = 0.10 - 0.63), and 2.33 (95% CI = 1.21 - 4.48) for women, and 0.92 (95% CI = 0.52 - 2.13), 3.01 (95% CI = 1.64 - 5.55), and 0.64 (95% CI = 0.25 - 1.62) for the patients who smoked, respectively. In addition, there was no significant association between the different disorders and age, marital status, history of relapse, and history of suicide.

Conclusions: The results showed that there was a greater risk of anxiety disorders with bipolar disorder than other disorders. While women with bipolar disorder were at higher risk of anxiety disorders and OCD, men were at greater risk of drug addiction.