Avicenna Journal of Neuro Psych Physiology Avicenna Journal of Neuro Psych Physiology Avicenna J Neuro Psych Physio http://www.avicennajnpp.com 2383-2436 2383-2444 10.5812/ajnpp. en jalali 2017 6 27 gregorian 2017 6 27 3 1
en 10.17795/ajnpp-38613 Frequency of Multiple Sclerosis (MS) Among Relatives of MS Patients in Hamadan Society, Iran Frequency of Multiple Sclerosis (MS) Among Relatives of MS Patients in Hamadan Society, Iran research-article research-article Patients and Methods

This cross-sectional study was performed on 1202 MS patients in Farshchian hospital, Hamadan, in 2013. All patients were diagnosed with definite MS. A questionnaire was used to gather information; demographic characteristics, medical history, signs and symptoms at onset, course of disease, relatives with MS, and degree and type of relationship were recorded.

Conclusions

There has been an increase in the rate of the disease in Hamadan province in recent years. It was found that there are lower rates of familial prevalence relative to this sample being studied in Hamadan society. The familial MS is more common among sisters. Further studies on the MS patients in Hamadan will be needed for a better assessment of familial and environmental factors.

Background

Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system with unknown causes. In the last decade, the prevalence of MS in Iran has increased.

Objectives

This study evaluated the frequency of familial MS among patients in the Hamadan society for MS.

Results

The mean age of the patients with familial MS was 28 ± 10.4 years, with higher rates among women (the female to male ratio was 3.2: 1). Familial MS was found in 8.65% of the patients, and 58.58% of those patients had a first-degree relative with MS. The highest rate for familial MS was observed in sister-sister relations and brother-sister relation. The MS risk changed from 57.69% in first-degree relatives to 35.57% in second-degree relatives and 6.73% in third-degree relatives.

Patients and Methods

This cross-sectional study was performed on 1202 MS patients in Farshchian hospital, Hamadan, in 2013. All patients were diagnosed with definite MS. A questionnaire was used to gather information; demographic characteristics, medical history, signs and symptoms at onset, course of disease, relatives with MS, and degree and type of relationship were recorded.

Conclusions

There has been an increase in the rate of the disease in Hamadan province in recent years. It was found that there are lower rates of familial prevalence relative to this sample being studied in Hamadan society. The familial MS is more common among sisters. Further studies on the MS patients in Hamadan will be needed for a better assessment of familial and environmental factors.

Background

Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system with unknown causes. In the last decade, the prevalence of MS in Iran has increased.

Objectives

This study evaluated the frequency of familial MS among patients in the Hamadan society for MS.

Results

The mean age of the patients with familial MS was 28 ± 10.4 years, with higher rates among women (the female to male ratio was 3.2: 1). Familial MS was found in 8.65% of the patients, and 58.58% of those patients had a first-degree relative with MS. The highest rate for familial MS was observed in sister-sister relations and brother-sister relation. The MS risk changed from 57.69% in first-degree relatives to 35.57% in second-degree relatives and 6.73% in third-degree relatives.

Multiple Sclerosis;Heredity;Prevalence;Hamadan Multiple Sclerosis;Heredity;Prevalence;Hamadan http://www.avicennajnpp.com/index.php?page=article&article_id=38613 Mehrdokht Mazdeh Mehrdokht Mazdeh Department of Neurology, Hamadan University of Medical Sciences, Hamadan, IR Iran Department of Neurology, Hamadan University of Medical Sciences, Hamadan, IR Iran Mojtaba Khazaei Mojtaba Khazaei Department of Neurology, Hamadan University of Medical Sciences, Hamadan, IR Iran; Department of Neurology, Hamadan University of Medical Sciences, Hamadan, IR Iran. Tel: +98-8118380315, Fax: +98-08138276010 Department of Neurology, Hamadan University of Medical Sciences, Hamadan, IR Iran; Department of Neurology, Hamadan University of Medical Sciences, Hamadan, IR Iran. Tel: +98-8118380315, Fax: +98-08138276010 Nasrin Hashemi-Firouzi Nasrin Hashemi-Firouzi Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Masoud Ghiasian Masoud Ghiasian Department of Neurology, Hamadan University of Medical Sciences, Hamadan, IR Iran Department of Neurology, Hamadan University of Medical Sciences, Hamadan, IR Iran