Avicenna Journal of Neuro Psycho Physiology

Published by: Kowsar

Frequency of Multiple Sclerosis (MS) Among Relatives of MS Patients in Hamadan Society, Iran

Mehrdokht Mazdeh 1 , Mojtaba Khazaei 1 , * , Nasrin Hashemi-Firouzi 2 and Masoud Ghiasian 1
Authors Information
1 Department of Neurology, Hamadan University of Medical Sciences, Hamadan, IR Iran
2 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran
Article information
  • Avicenna Journal of Neuro Psych Physiology: February 2016, 3 (1); e60194
  • Published Online: February 28, 2016
  • Article Type: Research Article
  • Received: January 1, 2016
  • Revised: January 15, 2016
  • Accepted: February 15, 2016
  • DOI: 10.17795/ajnpp-38613

To Cite: Mazdeh M, Khazaei M, Hashemi-Firouzi N, Ghiasian M. Frequency of Multiple Sclerosis (MS) Among Relatives of MS Patients in Hamadan Society, Iran, Avicenna J Neuro Psycho Physiology. 2016 ;3(1):e60194. doi: 10.17795/ajnpp-38613.

Copyright © 2016, Hamadan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. McFarlin DE, McFarland HF. Multiple sclerosis (second of two parts). N Engl J Med. 1982; 307(20): 1246-51[DOI][PubMed]
  • 2. Mao P, Reddy PH. Is multiple sclerosis a mitochondrial disease? Biochim Biophys Acta. 2010; 1802(1): 66-79[DOI][PubMed]
  • 3. Smestad C, Sandvik L, Holmoy T, Harbo HF, Celius EG. Marked differences in prevalence of multiple sclerosis between ethnic groups in Oslo, Norway. J Neurol. 2008; 255(1): 49-55[DOI][PubMed]
  • 4. Compston A, Coles A. Multiple sclerosis. Lancet. 2008; 372(9648): 1502-17[DOI][PubMed]
  • 5. Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, et al. Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun. 2011; 2: 334[DOI][PubMed]
  • 6. Javan MR, Seyfizadeh N, Aslani S, Farhoodi M, Babaloo Z. Molecular analysis of interleukin-25 exons 1 and 2 and its serum levels in Iranian patients with multiple sclerosis. Am J Clin Exp Immunol. 2014; 3(2): 91-6[PubMed]
  • 7. Binzer S, Imrell K, Binzer M, Vang S, Rogvi-Hansen B, Hillert J, et al. Multiple sclerosis in a family on the Faroe Islands. Acta Neurol Scand. 2010; 121(1): 16-9[DOI][PubMed]
  • 8. Ramagopalan SV, Handel AE, Giovannoni G, Rutherford Siegel S, Ebers GC, Chaplin G. Relationship of UV exposure to prevalence of multiple sclerosis in England. Neurology. 2011; 76(16): 1410-4[DOI][PubMed]
  • 9. Orton SM, Ramagopalan SV, Para AE, Lincoln MR, Handunnetthi L, Chao MJ, et al. Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians. J Neurol Sci. 2011; 305(1-2): 116-20[DOI][PubMed]
  • 10. Orton SM, Morris AP, Herrera BM, Ramagopalan SV, Lincoln MR, Chao MJ, et al. Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis. Am J Clin Nutr. 2008; 88(2): 441-7[PubMed]
  • 11. Milo R, Kahana E. Multiple sclerosis: geoepidemiology, genetics and the environment. Autoimmun Rev. 2010; 9(5)-94[DOI][PubMed]
  • 12. Browne P, Chandraratna D, Angood C, Tremlett H, Baker C, Taylor BV, et al. Atlas of Multiple Sclerosis 2013: A growing global problem with widespread inequity. Neurology. 2014; 83(11): 1022-4[DOI][PubMed]
  • 13. Kurtzke JF. Epidemiologic contributions to multiple sclerosis: an overview. Neurology. 1980; 30(7 Pt 2): 61-79[PubMed]
  • 14. Pugliatti M, Rosati G, Carton H, Riise T, Drulovic J, Vecsei L, et al. The epidemiology of multiple sclerosis in Europe. Eur J Neurol. 2006; 13(7): 700-22[DOI][PubMed]
  • 15. Mei FJ, Osoegawa M, Ochi H, Minohara M, Nan S, Murai H, et al. Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis. J Neurol Sci. 2006; 246(1-2): 71-7[DOI][PubMed]
  • 16. Pugliatti M, Sotgiu S, Rosati G. The worldwide prevalence of multiple sclerosis. Clin Neurol Neurosurg. 2002; 104(3): 182-91[PubMed]
  • 17. Zabihi R, Galehdari H, Shafiee M, Kazeminejad SR, Alavi SM. Analysis of HLA-DQB1*0602 in Multiple Sclerosis Patients in Khuzestan Province, Iran. Arch Iran Med. 2015; 18(10): 698-702[PubMed]
  • 18. Tolou-Ghamari Z. Preliminary Study of Differences Between Prevalence of Multiple Sclerosis in Isfahan and its’ Rural Provinces. Arch Neurosci. 2015; 2(4)
  • 19. Etemadifar M, Maghzi AH. Sharp increase in the incidence and prevalence of multiple sclerosis in Isfahan, Iran. Mult Scler. 2011; 17(8): 1022-7[DOI][PubMed]
  • 20. Etemadifar M, Janghorbani M, Shaygannejad V, Ashtari F. Prevalence of multiple sclerosis in Isfahan, Iran. Neuroepidemiology. 2006; 27(1): 39-44[DOI][PubMed]
  • 21. Yousefipour GA, Rasekhi A. Multiple sclerosis: risk factor analysis in Iran. 2002;
  • 22. Radmehr M, Meghdadi S, Bahmanzadeh M, Sabbagh S. Prevalence, Demographics and Clinical Characteristics of Multiple Sclerosis in North of Khuzestan Province, Iran. JJHR. 2015; 6(5)
  • 23. Sazdovitch V, Verdier-Taillefer MH, Heinzlef O, Alamowitch S, Roullet E. Familial multiple sclerosis: study of 357 consecutive patients. Revue neurolog. 2000; 156(6-7): 638-40
  • 24. Amela-Peris R, Aladro Y, Conde-Sendin MA, Alemany-Rodriguez MJ, Munoz-Fernandez C, Reyes-Yanez MP, et al. Familial multiple sclerosis in Canary Islands. Revista de neurologia. 2003; 39(10): 911-4
  • 25. Romero-Pinel L, Martinez-Yelamos S, Gubieras L, Matas E, Bau L, Kremenchutzky M, et al. Anticipation of age at onset in familial multiple sclerosis. Eur J Neurol. 2010; 17(4): 572-5[DOI][PubMed]
  • 26. Amela-Peris R, Aladro Y, Conde-Sendin MA, Alemany-Rodriguez MJ, Munoz-Fernandez C, Reyes-Yanez MP, et al. [Familial multiple sclerosis in Canary Islands]. Rev Neurol. 2004; 39(10): 911-4[PubMed]
  • 27. Laroni A, Calabrese M, Perini P, Albergoni MP, Ranzato F, Tiberio M, et al. Multiple sclerosis and autoimmune diseases: epidemiology and HLA-DR association in North-east Italy. J Neurol. 2006; 253(5): 636-9[DOI][PubMed]
  • 28. Willer CJ, Dyment DA, Risch NJ, Sadovnick AD, Ebers GC, Canadian Collaborative Study G. Twin concordance and sibling recurrence rates in multiple sclerosis. Proc Natl Acad Sci U S A. 2003; 100(22): 12877-82[DOI][PubMed]
  • 29. Mumford CJ, Wood NW, Kellar-Wood H, Thorpe JW, Miller DH, Compston DA. The British Isles survey of multiple sclerosis in twins. Neurology. 1994; 44(1): 11-5[PubMed]
  • 30. Hardy J, Thompson AJ. Dissecting the familial risk of multiple sclerosis. Ann Neurol. 2011; 69(1): 11-2[DOI][PubMed]
  • 31. Valadbeigi A, Weisi F, Rohbakhsh N, Rezaei M, Heidari A, Rasa A. Central auditory processing and word discrimination in patients with multiple sclerosis. European Archives of Oto-Rhino-Laryngology. 2014; 271(11): 2891-6
  • 32. Mazdeh M, Seifirad S, Kazemi N, Seifrabie MA, Dehghan A, Abbasi H. Comparison of vitamin D3 serum levels in new diagnosed patients with multiple sclerosis versus their healthy relatives. Acta medica Iranica. 2013; 51(5): 289-92
  • 33. Kurtzke JF. Multiple sclerosis in time and space--geographic clues to cause. J Neurovirol. 2000; 6 Suppl 2-40[PubMed]
  • 34. Fraser FC. Genetic counseling. Am J Hum Genet. 1974; 26(5): 636-59[PubMed]
  • 35. Harper PS. Practical genetic counselling. 2010;
  • 36. Association WM. Ethical principles for medical research involving human subjects. 2001; 79
  • 37. Toghianifar N, Etemadifar M, Sharifzadeh A, Nasr Z. Characteristics of familial multiple sclerosis in Isfahan, Iran: A cross-sectional study. Neurology Asia. 2014; 19(1)
  • 38. Hashemilar M, Savadi Ouskui D, Farhoudi M, Ayromlou H, Asadollahi A. Multiple sclerosis in East-Azerbaijan, north west Iran. Neurology Asia. 2011; 16(2): 127-31
  • 39. Al Jumah M, Kojan S, Al Khathaami A, Al Abdulkaream I, Al Blawi M, Jawhary A. Familial multiple sclerosis: does consanguinity have a role? Mult Scler. 2011; 17(4): 487-9[DOI][PubMed]
  • 40. Mackenzie IS, Morant SV, Bloomfield GA, MacDonald TM, O'Riordan J. Incidence and prevalence of multiple sclerosis in the UK 1990-2010: a descriptive study in the General Practice Research Database. J Neurol Neurosurg Psychiatry. 2014; 85(1): 76-84[DOI][PubMed]
  • 41. Lau KK, Wong WW, Sheng B, Yu IT, Fung BH, Li HL, et al. The clinical course of multiple sclerosis patients in Hong Kong. J Neurol Sci. 2008; 268(1-2): 78-82[DOI][PubMed]
  • 42. Farez MF, Balbuena Aguirre ME, Varela F, Kohler AA, Nagel V, Correale J. Low familial risks for multiple sclerosis in Buenos Aires, Argentina. J Neurol Sci. 2014; 346(1-2): 268-70[DOI][PubMed]
  • 43. Mazdeh M, Afzali S, Jaafari MR. The therapeutic effect of Avonex, Rebif and Betaferon on EDSS and relapse in multiple sclerosis: a comparative study. Acta Med Iran. 2010; 48(2): 83-8[PubMed]
  • 44. Majdinasab N, Hosseini Behbahani M, Galehdari H, Mohaghegh M. Association of interleukin 7 receptor gene polymorphism rs6897932 with multiple sclerosis patients in Khuzestan. Iran J Neurol. 2014; 13(3): 168-71[PubMed]
  • 45. Orton SM, Wald L, Confavreux C, Vukusic S, Krohn JP, Ramagopalan SV, et al. Association of UV radiation with multiple sclerosis prevalence and sex ratio in France. Neurology. 2011; 76(5): 425-31[DOI][PubMed]
  • 46. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006; 296(23): 2832-8[DOI][PubMed]
  • 47. Rezaali S, Khalilnezhad A, Naser Moghadasi A, Chaibakhsh S, Sahraian MA. Epidemiology of multiple sclerosis in Qom: Demographic study in Iran. Iran J Neurol. 2013; 12(4): 136-43[PubMed]
  • 48. Adams CW, Hallpike JF. The aetiology and pathogenesis of multiple sclerosis. Guys Hosp Rep. 1969; 118(2): 263-86[PubMed]
  • 49. Mazzucchelli RI, Riva A, Durum SK. The human IL-7 receptor gene: deletions, polymorphisms and mutations. Semin Immunol. 2012; 24(3): 225-30[DOI][PubMed]
  • 50. Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983; 13(3): 227-31[DOI][PubMed]
  • 51. Josey L, Curley M, Jafari Mousavi F, Taylor BV, Lucas R, Coulthard A. Imaging and diagnostic criteria for Multiple Sclerosis: are we there yet? J Med Imaging Radiat Oncol. 2012; 56(6): 588-93[DOI][PubMed]
  • 52. Sawcer S, Compston A. The genetic analysis of multiple sclerosis in Europeans: concepts and design. J Neuroimmunol. 2003; 143(1-2): 13-6[PubMed]
  • 53. Sadovnick AD. Differential effects of genetic susceptibility factors in males and females with multiple sclerosis. Clin Immunol. 2013; 149(2): 170-5[DOI][PubMed]
  • 54. Azarpira N, Borhani Haghighi A, Pourjafar M, Shariat A. Interleukin 10 gene polymorphism in Iranian patients with multiple sclerosis. Acta Neurol Taiwan. 2010; 19(2): 107-11[PubMed]
  • 55. Dyment DA, Sadovnick AD, Ebers GC. Genetics of multiple sclerosis. Hum Mol Genet. 1997; 6(10): 1693-8[PubMed]
  • 56. Disanto G, Morahan JM, Ramagopalan SV. Multiple sclerosis: risk factors and their interactions. CNS Neurol Disord Drug Targets. 2012; 11(5): 545-55[PubMed]
  • 57. Ascherio A. Environmental factors in multiple sclerosis. Expert Rev Neurother. 2013; 13(12 Suppl): 3-9[DOI][PubMed]
  • 58. Smolders J, Damoiseaux J, Menheere P, Tervaert JW, Hupperts R. Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis. Ann N Y Acad Sci. 2009; 1173: 515-20[DOI][PubMed]
  • 59. Marrie RA. Environmental risk factors in multiple sclerosis aetiology. Lancet Neurol. 2004; 3(12): 709-18[DOI][PubMed]
  • 60. Lonergan R, Kinsella K, Fitzpatrick P, Brady J, Murray B, Dunne C, et al. Multiple sclerosis prevalence in Ireland: relationship to vitamin D status and HLA genotype. J Neurol Neurosurg Psychiatry. 2011; 82(3): 317-22[DOI][PubMed]
  • 61. Islam T, Gauderman WJ, Cozen W, Mack TM. Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins. Neurology. 2007; 69(4): 381-8[DOI][PubMed]
  • 62. Niino M, Miyazaki Y. [Vitamin D in Multiple Sclerosis]. Brain Nerve. 2015; 67(11): 1429-33[DOI][PubMed]
  • 63. Baarnhielm M, Hedstrom AK, Kockum I, Sundqvist E, Gustafsson SA, Hillert J, et al. Sunlight is associated with decreased multiple sclerosis risk: no interaction with human leukocyte antigen-DRB1*15. Eur J Neurol. 2012; 19(7): 955-62[DOI][PubMed]
  • 64. Niino M, Miyazaki Y, Fukazawa T, Kikuchi S. [Vitamin D and latitude as environmental factors in multiple sclerosis]. Nihon Rinsho. 2014; 72(11): 1924-9[PubMed]
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